John C Burnett Selected Research

Atrial Natriuretic Factor (ANF)

1/2022	MANP (M-Atrial Natriuretic Peptide) Reduces Blood Pressure and Furosemide-Induced Increase in Aldosterone in Hypertension.
12/2021	Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.
12/2021	First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension.
1/2021	Natriuretic Peptides and Blood Pressure Homeostasis: Implications for MANP, a Novel Guanylyl Cyclase a Receptor Activator for Hypertension.
1/2021	Atrial Natriuretic Peptide and Treatment With Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction.
1/2020	Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP.
12/2019	Atrial Natriuretic Peptide, Heart Failure and the Heart as an Endocrine Organ.
10/2019	Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP.
7/2019	Atrial Natriuretic Peptide: A Molecular Target of Novel Therapeutic Approaches to Cardio-Metabolic Disease.
1/2019	Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

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John C Burnett Research Topics

Disease

133	Heart Failure 01/2022 - 02/2002
35	Hypertension (High Blood Pressure) 01/2022 - 01/2002
25	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 02/2003
16	Fibrosis (Cirrhosis) 05/2017 - 04/2003
9	Left Ventricular Dysfunction 01/2020 - 06/2002
8	Hypertrophy 12/2021 - 03/2003
7	Obesity 01/2017 - 07/2009
6	Inflammation (Inflammations) 01/2020 - 07/2010
6	Hypotension (Low Blood Pressure) 10/2019 - 01/2008
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2019 - 08/2011
6	Body Weight (Weight, Body) 07/2012 - 05/2005
6	Heart Diseases (Heart Disease) 03/2011 - 05/2005
5	Myocardial Infarction 01/2021 - 11/2006
5	Atrial Fibrillation 01/2020 - 07/2008
4	Infections 03/2022 - 01/2015
4	Renal Insufficiency (Renal Failure) 04/2021 - 05/2006
4	Atherosclerosis 10/2019 - 01/2002
4	Metabolic Diseases (Metabolic Disease) 07/2019 - 01/2015
4	Chronic Renal Insufficiency 01/2016 - 01/2015
4	Dyspnea (Shortness of Breath) 07/2012 - 03/2007
4	Edema (Dropsy) 06/2011 - 05/2003
4	Cardiomyopathies (Cardiomyopathy) 05/2007 - 08/2005
3	HIV Infections (HIV Infection) 01/2022 - 01/2012
3	Systolic Heart Failure 04/2021 - 12/2012
3	Disease Progression 01/2019 - 04/2009
3	Stroke (Strokes) 02/2015 - 05/2010
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2015 - 05/2006
3	Acquired Immunodeficiency Syndrome (AIDS) 01/2015 - 10/2012
3	Neoplasms (Cancer) 01/2012 - 09/2011
3	Cardiomegaly (Heart Hypertrophy) 12/2010 - 08/2005
2	Essential Hypertension 01/2021 - 01/2021
2	Chronic Disease (Chronic Diseases) 12/2019 - 01/2015
2	Ischemia 10/2019 - 06/2006
2	Abdominal Obesity 12/2015 - 01/2015
2	Ventricular Dysfunction 01/2014 - 06/2004
2	Ventricular Remodeling 03/2013 - 01/2004
2	Cardio-Renal Syndrome 03/2013 - 01/2007

Drug/Important Bio-Agent (IBA)

58	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2021 - 02/2002
47	Natriuretic PeptidesIBA 01/2022 - 02/2002
32	Atrial Natriuretic Factor (ANF)IBA 01/2022 - 06/2002
29	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2002
18	AldosteroneIBA 01/2022 - 04/2004
16	Peptides (Polypeptides)IBA 01/2021 - 01/2004
16	pro-brain natriuretic peptide (1-76)IBA 01/2021 - 04/2005
11	Tolvaptan FDA Link 07/2012 - 05/2005
10	DiureticsIBA 07/2012 - 02/2002
9	Hormones (Hormone)IBA 01/2021 - 04/2004
8	Angiotensin IIIBA 01/2014 - 05/2003
8	SodiumIBA 07/2012 - 01/2004
8	Vasopressins (Vasopressin)IBA 07/2012 - 05/2005
7	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022 - 12/2018
7	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2021 - 02/2011
7	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2018 - 04/2004
6	Proteins (Proteins, Gene)FDA Link 05/2017 - 09/2002
5	Furosemide (Lasix)FDA LinkGeneric 01/2022 - 04/2004
5	ReninIBA 01/2021 - 02/2002
5	LigandsIBA 01/2017 - 06/2009
5	Soluble Guanylyl CyclaseIBA 01/2014 - 02/2003
4	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022 - 10/2006
4	Cyclic GMPIBA 01/2022 - 12/2010
4	Pharmaceutical PreparationsIBA 01/2022 - 01/2006
4	CreatinineIBA 04/2021 - 04/2003
4	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 01/2007
4	atrial natriuretic factor receptor AIBA 01/2021 - 01/2019
4	AngiotensinsIBA 01/2021 - 01/2004
4	CollagenIBA 04/2016 - 01/2004
4	SaltsIBA 01/2015 - 02/2008
4	Neurotransmitter Agents (Neurotransmitter)IBA 04/2011 - 03/2005
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 04/2021 - 12/2018
3	Neprilysin (Neutral Endopeptidase)IBA 01/2020 - 12/2018
3	Biological ProductsIBA 01/2020 - 05/2007
3	LipidsIBA 12/2019 - 12/2015
3	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 10/2019 - 02/2002
3	cenderitideIBA 04/2019 - 12/2016
3	HDL CholesterolIBA 01/2017 - 08/2011
3	CytokinesIBA 02/2016 - 03/2003
3	salicylhydroxamic acid (SHAM)IBA 05/2012 - 07/2010
3	Acetates (Acetic Acid Esters)FDA Link 09/2010 - 02/2008
3	Desoxycorticosterone (Deoxycorticosterone)IBA 09/2010 - 02/2008
3	MineralocorticoidsIBA 07/2010 - 09/2007
3	Endothelin-1 (Endothelin 1)IBA 03/2005 - 01/2004
2	RNA (Ribonucleic Acid)IBA 03/2022 - 01/2012
2	Tadalafil (Cialis)FDA Link 01/2022 - 04/2016
2	CRRL269IBA 10/2019 - 01/2018
2	Triglycerides (Triacylglycerol)IBA 01/2017 - 01/2015
2	Matrix Metalloproteinases (MMPs)IBA 02/2016 - 01/2004
2	EnzymesIBA 02/2016 - 01/2007
2	CholesterolIBA 02/2015 - 10/2013
2	procollagen Type III-N-terminal peptide (PIIP)IBA 01/2015 - 04/2011
2	Messenger RNA (mRNA)IBA 01/2015 - 01/2013
2	Pro-BNP1-108IBA 01/2015 - 06/2013
2	FurinIBA 11/2014 - 01/2013
2	Guanylate Cyclase (Guanylyl Cyclase)IBA 10/2014 - 01/2014
2	TroponinIBA 09/2014 - 05/2007
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2013 - 01/2007
2	Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OHIBA 09/2012 - 11/2011

Therapy/Procedure

46	Therapeutics 01/2022 - 02/2002
5	Nephrectomy 01/2015 - 02/2008
3	Transplantation 01/2009 - 04/2003
2	Drug Therapy (Chemotherapy) 12/2018 - 01/2016